The Effect of "Melanin-Gel" on the Wound Healing

Despite advances in traumatic wound care and management, infections remain a leading cause of mortality, morbidity and economic disruption in millions of wound patients around the world. Animal models have become standard tools for studying a wide array of external traumatic wound infections and testing new antimicrobial strategies. Study of wound-healing action was conducted on model of full-thickness skin wound, purulent necrotic wound and thermal burns. The efficiency of wounds treatment with Melanin that is produced by Antarctic black yeast-like fungi Nadsoniella nigra strain X1-M was studied. "Melanin-gel" (0.05% melanin dissolved in 0.5% carbopol) had antimicrobial property against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, that is one of the mechanisms of wound healing. Application of the "Melanin-gel on wound area enhanced wound cleaning from dead tissue and reduced eschar, stimulated the early growth of granulation tissue, and improved epithelialization of the wound.